1. Immunosuppressant drugs and renal transplant: Practical considerations for the use of tacrolimus

    Renal transplant patient care poses challenges such as maintaining a reasonable balance between efficacy and toxicity of immunosuppression. Different regimens of immune-suppressants are available and are determined by local protocols, aiming to address different levels of immunological risk. Owing to the narrow therapeutic index and large intra- and interpatient variability, drug monitoring of especially the calcineurin agents, continues to play an important role in the management of these patients.

  2. Coeliac disease

    Gluten related disorders can be classified according to pathogenesis: Autoimmune disease (Coeliac disease, dermatitis herpetiformis, gluten ataxia), non autoimmune disease (related to gluten sensitivity) and allergic disease (wheat allergy).